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最近の発表


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一般の皆さまへ
「最近の発表」  '98~'12
2015年度   2014年度  2013年度  2012年度  2011年度 2010年度 2009年度 2008年度  2007年度  2005~2006年度 2001~2004年度   2000年度以前 
2015年(平成27年)                              上へ
 Iuchi, K., Imoto A., Kamimura N., Ichimiya H., Yokota T., Ohta S.(2016): Molecular hydrogen regulates gene expression by modifying the free radical chain reaction-dependent generation of oxidized phospholipid mediators. Sci Rep.6:18971.
 
2014年(平成26年)                       上へ
Hayashida, K., Sano, M., Kamimura, N., Yokota, T., Suzuki, M., Ohta, S., Fukuda, K., Hori, S(2014).: Hydrogen Inhalation During Normoxic Resuscitation Improves Neurological Outcome in a Rat Model of Cardiac Arrest, Independent of Targeted Temperature Management. Circulation. ;130(24):2173-80.
Yokota, T., Kamimura, N., Igarashi, T,, Takahashi, H., Ohta, S., Oharazawa, H(2015).: Protective effect of molecular hydrogen against oxidative stress caused by peroxynitrite derived from nitric oxide in rat retina. Clin Experimental Ophthalmol. in press.
Kanamaru, T., Kamimura, N., Yokota, T., Nishimaki, K., Iuchi, K., Lee H., Takami, S., Akashiba, H.1,, Shitaka, Y., Ueda, M., Katsura, KI, Kimura, K., Ohta, S. (2015): Intravenous transplantation of bone marrow-derived mononuclear cells prevents memory impairment in transgenic mouse models of Alzheimer's disease. Brain Res. in press.
Kanamaru, T., Kamimura, N., Yokota, T., Iuchi, K., Nishimaki, K., Takami, S., Akashiba, H., Shitaka Y., Katsura K., Kimura, K., Ohta, S. (2015): Oxidative stress accelerates amyloid deposition and memory impairment in a double-transgenic mouse model of Alzheimer's disease. Neurosci Lett.;587:126-31.
Yokoyama, M., Okada, S., Nakagomi, A., Moriya, J., Shimizu, I., Nojima, A., Yoshida, Y., Ichimiya, H., Kamimura, N., Kobayashi, Y., Ohta, S., Fruttiger, M., Lozano, G., Minamino, T.(2014):Inhibition of endothelial p53 improves metabolic abnormalities related to dietary obesity. Cell Rep. ;7(5):1691-703.
Nakashima, Y., Ohsawa, I, Nishimaki, K., Kumamoto, S., Maruyama, I., Suzuki, Y., Ohta, S.(2014): Preventive effects of Chlorella on skeletal muscle atrophy in muscle-specific mitochondrial aldehyde dehydrogenase 2 activity-deficient mice. BMC Complement Altern Med. 14:390
  Wolf AM, Nishimaki K, Kamimura N, Ohta S(2014).: Real-Time Monitoring of Oxidative Stress in Live Mouse Skin. J Invest Dermatol.134(6):1701-9.
  Lee H, Kiuchi T, Muto J, Ohta S., Mikami T(2014).Intense exercise enhances the hippocampal proliferation of progenitor cells via activating the Flk1 signaling cascade in mice. GAZZETA MEDICA ITALIANA ARCHIVIO PER LE SCIENZE MEDICHE A Journal on Internal Medicine and Pharmacology i173:329-40.
2013年(平成25年)                              上へ
 Lee H, Ohno M, Ohta S, Mikami T. (2013)Regular Moderate or Intense Exercise Prevents Depression-Like Behavior without Change of Hippocampal Tryptophan Content in Chronically Tryptophan-Deficient and Stressed Mice. PLoS One. ;8(7):e66996.
  Takahashi M, Wolf AM, Watari E, Norose Y, Ohta S, Takahashi H(2013 ).Increased mitochondrial functions in human glioblastoma cells persistently infected with measles virus. Antiviral Res. 99(3):238-244.
 Yoritaka A, Takanashi M, Hirayama M, Nakahara T, Ohta S, Hattori N(2013) Pilot study of H(2) therapy in Parkinson's disease: A randomized double-blind placebo-controlled trial. Mov Disord. 28(6):836-839.


日本医科大学
大学院
医学研究科
加齢科学系専攻
細胞生物学分野

    (先端医学研究所     細胞生物学部門)

Fax: 044-733-9268


本ページに記載の記事・写真・カットの転載を禁じます。すべての著作権は生化学部門に帰属します。

(C)Copyright 2001, Dept. of Biochem. and Cell Biol.

最終更新日
16.01.16


Nojima A, Yamashita M, Yoshida Y, Shimizu I, Ichimiya H, Kamimura N, Kobayashi Y, Ohta S, Ishii N, Minamino T.(2013)Haploinsufficiency of akt1 prolongs the lifespan of mice. PLoS One. 8(7):e69178.
 2012年(平成24年)                          上へ
 Hayashida K, Sano M, Kamimura N, Yokota T, Suzuki M, Maekawa Y, Kawamura A, Abe T, Shigeo Ohta S, Fukuda K, Hori S.(2012) H2 gas improves functional outcome after cardiac arrest to an extent comparable to therapeutic hypothermia. J. Am. Heart Assoc. ;1(5):e003459
 .Hoshi H, Hao W, Fujita Y, Funayama A, Miyauchi Y, Hashimoto K, Miyamoto K, Iwasaki R, Sato Y, Kobayashi T, Miyamoto H, Yoshida S, Mori T, Kanagawa H, Katsuyama E, Fujie A, Kitagawa K, Nakayama KI, Kawamoto T, Sano M, Fukuda K, Ohsawa I, Ohta S, Morioka H, Matsumoto M, Chiba K, Toyama Y, Miyamoto T. (2012) Aldehyde-stress resulting from Aldh2 mutation promotes osteoporosis due to impaired osteoblastogenesis. J Bone Miner Res. 27(9):2015-2023
 Rikimaru M, Ohsawa Y, Wolf AM, Nishimaki K, Ichimiya H, Kamimura N, Nishimatsu S-i, Ohta S, Sunada Y.(2012).: Taurine ameliorates impaired mitochondrial function and prevents stroke-like episodes in patients with MELAS. Intern. Med. ;51(24):3351-7.
 Koga Y, Tanaka M, Ohta S, Wei YH.(2012) Biochemistry of mitochondria, life and intervention 2010. Biochim Biophys Acta. 1820(5):551-552
 Sakurazawa M, Katsura K, Saito M, Asoh S, Ohta S, Katayama Y.(2012) Mild hypothermia enhanced the protective effect of protein therapy with transductive anti-death FNK protein using a rat focal transient cerebral ischemia model. Brain Res. 1430:86-92.
 Kashio A, Sakamoto T, Kakigi A, Suzuki M, Suzukawa K, Kondo K, Sato Y, Asoh S, Ohta S, Yamasoba T. (2011) Topical application of the antiapoptotic TAT-FNK protein prevents aminoglycoside-induced ototoxicity. Gene Ther. 19(12)1141-1149.
 Cheng A, Wan R, Yang JL, Kamimura N, Son TG, Ouyang X, Luo Y, Okun E, Mattson MP. (2012) Involvement of PGC-1α in the formation and maintenance of neuronal dendritic spines. Nat Commun. 3, 1250-1261
 Sodeoka M, Dodo K, Teng Y, Iuchi K, Hamashima Y, Iwasa E, Shinya Fujishiro S(2012) Biological Activities of Chaetocin and its Derivatives. Pure & Appl. Chem. 84(6), 1369–1378.
 Murasawa S, Iuchi K, Sato S, Noguchi-Yachide T, Sodeoka M, Yokomatsu T, Dodo K, Hashimoto Y, Aoyama H(2012). Small-molecular Inhibitors of Ca2+-induced Mitochondrial Permeability Transition (MPT) Derived from Muscle Relaxant Dantrolene Bioorg. Med. Chem. 20, 6384-6393.
 2011年(平成23年)                             上へ
 Kamimura N, Nishimaki K, Ohsawa I, Ohta S.(2011) Molecular Hydrogen Improves Obesity and Diabetes by Inducing Hepatic FGF21 and Stimulating Energy Metabolism in db/db Mice. Obesity (Silver Spring). 19(7):1396-1403.
 Shinmura K, Tamaki K, Adachi T, Sano M, Kamimura N, Wolf AM, Amo T, Ohta S, Katsumata Y, Fukuda K, Ishiwata K, Suematsu M.(2011) Caloric Restriction Primes Mitochondria for Ischemic Stress by Deacetylating Specific Mitochondrial Proteins of the Electron Transport Chain. Cir Res 109(4):396-406.
 Hanaoka T, Kamimura N, Yokota T, Takai S and Ohta S.(2011) Molecular hydrogen protects chondrocytes from oxidative stress and indirectly alters gene expressions through reducing peroxynitrite derived from nitric oxide. Medical Gas Research 1:18.
 Terasaki Y, Ohsaw, I, Terasaki M, Takahashi M, Kunugi S, Dedong K, Urushiyama H, Amenomori1 S, Kaneko-Togashi M, Kuwahara N, Ishikawa A, Kamimura N, Ohta S, and Fukuda Y.(2011) Hydrogen therapy attenuates irradiation-induced lung damage by reducing oxidative stress. Am J Physio. Lung Cellular and Mol. Physio. 301(4):L415-26.
 Nagare T, Sakaue H, Matsumoto M, Cao Y, Inagaki K, Sakai M, Takashima Y, Nakamura K, Mori T, Okada Y, Matsuki Y, Watanabe E, Ikeda K, Taguchi R, Kamimura N, Ohta S, Hiramatsu R, Kasuga M.(2-11) Overexpression of KLF15 Transcription Factor in Adipocytes of Mice Results in Down-regulation of SCD1 Protein Expression in Adipocytes and Consequent Enhancement of Glucose-induced Insulin Secretion. J Biol Chem. 2011 Oct 28;286(43):37458-69.
 太田成男(2010) 水素水の抗酸化作用;水素水は体にいいか? 温泉科学60(3):375-379.
 2010年(平成22年)                           上へ
 Kamimura N, Nishimaki K, Ohsawa I, Ohta S,(2011)Molecular Hydrogen Improves Obesity
and Diabetes by Inducing Hepatic FGF21 and Stimulating Energy Metabolism in db/db Mice.Obesity [Epub ahead of print]
 Amo T, Sato S, Saiki S, Wolf AM, Toyomizu M, Gautier CA, Shen J, Ohta S, Hattori N.(2011)Mitochondrial membrane potential decrease caused by loss of PINK1 is not due to proton leak, but to respiratory chain defects. Neurobiol Dis.41(1):111-118.
 Wolf, AM., Asoh, S., Hiranuma, H., Ohsawa, I., Iio, K., Satou, A., Ishikura, M., Ohta, S. (2010)Astaxanthin protects mitochondrial redox state and functional integrity against oxidative stress. J .Nutr. Biochem. 21(5):381-389.
 Nakajima, S., Ohsawa, I., Ohta, S., Ohno, M., Mikami, T.(2010)Regular voluntary exercise cures stress-induced impairment of cognitive function and cell proliferation accompanied by increases in cerebral IGF-1 and GST activity in mice. Behav Brain Res. 211(2):178-184.
 2009年(平成21年)                           上へ
 Endo J, Sano M, Katayama T, Hishiki T, Shinmura K, Morizane S, Matsuhashi T, Katsumata Y, Zhang Y, Ito H, Nagahata Y, Marchitti S, Nishimaki K, Wolf AM, Nakanishi H, Hattori F, Vasiliou V, Adachi T, Ohsawa I, Taguchi R, Hirabayashi Y, Ohta S, Suematsu M, Ogawa S, Fukuda K.(2010)Metabolic Remodeling Induced by Mitochondrial Aldehyde Stress Stimulates Tolerance to Oxidative Stress in the Heart.Circ Res. 105(11):1118-1127.
 Matuda S, Arimura T, Kimura A, Takekura H, Ohta S, Nakano K.(2010)A novel protein found in the I bands of myofibrils is produced by alternative splicing of the DLST gene. Biochim Biophys Acta. 1800(1):31-39.
 Oharazawa H, Igarashi T, Yokota T, Fujii H, Takahashi H, Ohta S and Ohsawa I.(2010)Rapid Diffusion of Hydrogen Protects the Retina: Administration to the Eye of Hydrogen-Containing Saline in Retinal Ischemia-Reperfusion Injury. Invest. Ophthalmol. Vis. Sci. 51(1):487-492.
Wan R., Ahmet I., Brown M., Cheng A., Kamimura N., Talan M., Mattson M.P.(2010) Cardioprotective effect of intermittent fasting is associated with an elevation of adiponectin levels in rats. J. Nutr. Biochem. 21(5):413-417.
Nakashima Y, Ohsawa I, Konishi F, Hasegawa T, Kumamoto S, Suzuki Y and Ohta S.(2009)  Preventive effects of Chlorella on cognitive decline in age-dependent dementia model mice. Neurosci Lett. 464(3):193-198.
Nakajima, S., Ohsawa,I., nagata, K., Ohta, S.,Ohno, M., Ijichi, T., Mikami, T.(2009) Oral supplementation with melon superoxide dismutase extract promotes antioxidant defences in the brain and prevents stress-induced impairment of spatial memory Behavioural. Brain Research 200 (1):15-21.
Suzuki, Y., Sano, M., Hayashida, K., Ohsawa, I., Ohta, S., Fukuda K.(2009)Are the effects of a-glucosidase inhibitors on cardiovascular events related to elevated levels of hydrogen gas in the gastrointestinal tract? FEBS Letters 583(13):2157-2159.
Nagata, K., Nakashima-Kamimura, N., Mikami, T., Ohsawa, I., Ohta ,S.(2009) Consumption of Molecular Hydrogen Prevents the Stress-Induced Impairments in Hippocampus-Dependent Learning Tasks during Chronic Physical Restraint in Mice. Neuropsychopharmacology. 34:501-508.
Harita, Y., Kurihara, H., Kosako, H., Tezuka, T., Sekine, T., Igarashi, T., Ohsawa, I., Ohta, S., Hattori, S.(2009)Phosphorylation of nephrin triggers Ca2+ signaling by recruitment and activation of phospholipase C-gamma 1.J. Biol. Chem. 284:(13)8951-8962.
Nakashima-Kamimura, N., Mori, T., Ohsawa, I., Asoh, S., and Ohta, S. (2009)Molecular hydrogen alleviates nephrotoxicity induced by an anti-cancer drug cisplatin without compromising anti-tumor activity in mice. Cancer Chemother Phrmacol. 64(4):753-761.
Fu, Y., Ito, M., Fujita, Y., Ito, M., Ichihara, M., Masuda, A., Suzuki, Y., Maesawa, S., Kajita, Y., Hirayama, M., Ohsawa, I., Ohta, S., Ohno, K.(2009)Molecular hydrogen is protective against 6-hydroxydopamine-induced nigrostriatal degeneration in a rat model of Parkinson's disease. Neurosci. Lett. 453(2):81-85.
Murakami, Y., Ohsawa, I., Kasahara, T., Ohta, S.(2009)Cytoprotective role of mitochondrial amyloid beta peptide-binding alcohol dehydrogenase against a cytotoxic aldehyde.Neurobiol Aging. 30(2):325-329.
Mizutani, S., Miyato, Y., Shidara, Y., Asoh, S., Tokunaga, A., Tajiri T., Ohta, S(2009)Mutations in the mitochondrial genome confer resistance of cancer cells to anti-cancer drugs Cancer Sci. 100(9):1680-1687.
Nakachi, N, Asoh, S., Watanabe, N., Mori, T., Matsushita, T., Takai, S. and Ohta, S.(2009) Transduction of Anti-Cell Death Protein FNK Suppresses Graft Degeneration after Autologous Cylindrical Osteochondral Transplantation. J. Histochem. Cytochem. 57(3):197-206.
2008年度(平成20年)                                  上へ
Ohsawa, I., Nishimaki, K., Yamagata, K., Ishikawa, M., Ohta, S. (2008) Consumption of hydrogen water prevents atherosclerosis in apolipoprotein E knockout mice. Biochem. Biophys. Res. Commun. 26;377(4):1195-1198.
Nishino, N., Tamori, Y., Tateya, S., kawagychi, T., Shibakusa, T., Mizunoya, W., Inoue, K., Kitazawa, R., Kitazawa, S., Matsuki, Y., Hiramatsu, R., Masubuchi, S., Omachi, A., Kimura, K., Saito, M., Amo, T., Ohta, S., Yamaguchi T., Osumi, T., Cheng, J., Fujimoto, T., Nakao, H., Nakano, K., Aiba, A., Okamura, H., Fushiki, T., Kasuga, M.(2008) FSP27 contributes to efficient energy storage in murine white adipocytes by promoting the formation of unilocular lipid droplets. J. Clin. Invest. 118:2808-2821.
Watanabe, M., Katsura, KI., Ohsawa, I., Mizukoshi, G., Takahashi, K., Asoh, S., Ohta, S., Katayama, Y.(2008) Involvement of mitoK(ATP) channel in protective mechanisms of cerebral ischemic tolerance. Brain Res. 1238:199-207.
Ohsawa, I., Nishimaki, K., Murakami, Y., Suziki Y., Ishikawa, M., Ohta S.(2008) Age-Dependent Neurodegeneration Accompanying Memory Loss in Transgenic Mice Defective in Mitochondrial Aldehyde Dehydrogenase 2 Activity. J. Neurosci. 28: 6239-6249.
Hayashida, K., Sano M., Ohsawa, I., Shinmura, K., Tamaki, K., Kimura, K., Endo, J., Katayama, T., Kawamura, A., Kohsaka, S., Makino, S., Ohta, S., Ogawa, S., Fukuda, K.(2008) Inhalation of hydrogen gas reduces infarct size in the rat model of myocardial ischemia-reperfusion injury. Biochem. Biophys. Res. Commun. 373:30-35.
Katsura, K., Takahashi, K., Asoh, S., Watanabe, M., Sakurazawa, M., Ohsawa, I., Mori, T., Igarashi, H., Ohkubo, S., Katayama, Y., Ohta, S. (2008) Combination therapy with transductive anti-death FNK protein and FK506 ameliorates brain damage with focal transient ischemia in rat. J. Neurochem. 106: 258-270.
Ohta, Y., Kamiya, T., Nagai, M., Nagata, T., Morimoto, N., Miyazaki, K., Murakami, T., Kurata, T., Takehisa, Y., Ikeda, Y., Asoh, S., Ohta, S., Abe, K. (2008) Therapeutic benefits of intrathecal protein therapy in a mouse model of amyotrophic lateral sclerosis. J. Neurosci. Res. 86:3028-3037.
Asoh, S., Ohta, S.(2008) PTD-mediated delivery of anti-cell death proteins/peptides and therapeutic enzymes. Adv. Drug. Deliv. Rev. 60: 499-516.
Nakashima-Kamimura,N., Nishimaki,K., Mori, T., Asoh, S., Ohta, S.(2008) Prevention of chemotherapy-Induced alopecia by anti-death FNK protein. Life Sci. 82: 218-225.
Kogiku M, Ohsawa I, Matsumoto K, Sugisaki Y, Takahashi H, Teramoto A, Ohta S.(2008)Prognosis of glioma patients by combined immunostaining for survivin, Ki-67 and epidermal growth factor receptor. J Clin Neurosci. 2008 Nov;15(11):1198-203.
Amo, T., Yadava, N., Oh, R., Nicholls, DG., Brand, MD.(2008) Experimental assessment of bioenergetic differences caused by the common European mitochondrial DNA haplogroups H and T. Gene. 411:69-76.
2007年度(平成19年)                                  上へ
Chen, H., Zhang, L., Jin,Z., Enjing Jin,E., Fujiwara,M., Ghazizadeh,M., Asoh,S., Ohta,S., Kawanami,O.(2007)Anti-apoptotic PTD-FNK protein suppresses lipopolysaccharide-induced acute lung injury in rats Experimental and Molecular Pathology. Exp. Mol. Pathol. 83: 377-384.
Murakami, Y., Aizu-Yokota, E., Sonoda, Y., Ohta, S., Kasahara, T.(2007)Suppression of endoplasmic reticulum stress-induced caspase activation and cell death by the overexpression of Bcl-xL or Bcl-2.J Biochem. 141:401-410.
Fukuda, KI., Asoh, S., Ishikawa, M., Yamamoto.Y., Ohsawa, I., Ohta.S.(2007) Inhalation of hydrogen gas suppresses hepatic injury caused by ischemia/reperfusion through reducing oxidative stress. Biochem. Biophys. Res. Commun. 361:670-674.
Ohsawa, I., Ishikawa, M., Takahashi, K., Watanabe, M., Nishimaki, K., Yamagata, K., Katsura, K.-I., Katayama, Y., Asoh, S., Ohta, S. (2007)Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals. Nat. Med. 13:688-694.
Arakawa, M., Yasutake, M., Asoh, S., Miyamoto, M., Takano, T., Ohta, S.(2007)Transduction of anti-cell death protein FNK protects isolated rat hearts from myocardial infarction induced by ischemia/reperfusion. Life Sci. 80 :2076-2084.
Kashio, A., Sakamoto, T., Suzukawa, K., Asoh, S., Ohta, S., Yamasoba, T. (2007) A Protein Derived From the Fusion of TAT Peptide and FNK, a Bcl-XL Derivative, prevents Cochlear Hair Cell Death From Aminoglycoside Ototoxicity In Vivo. J. Neurosci. Res. 85:1403-1412.
Tara, S., Miyamoto, M., Asoh, S., Ishii, N., Yasutake, M., Takagi, G., Takano, T., Ohta, S.(2007) Transduction of the anti-apoptotic PTD-FNK protein improves the efficiency of transplantation of bone marrow mononuclear cells. J. Mol. Cell. Cardiol. 42: 489-497.
Nagai, S., Asoh, S., Kobayashi, Y., Shidara, Y., Mori, T., Suzuki, M., Moriyama, Y., Ohta, S.(2007) Protection of hepatic cells from apoptosis induced by ischemia/reperfusion injury by protein therapeutics. Hepatol. Res. 37:133-142.
Liu, Q-X., Nakashima-Kamimura, N., Ikeo, K., Hirose, S., Gojobori, T. (2007) Compensatory Change of Interacting Amino Acids in the Coevolution of Transcriptional Coactivator MBF1 and TATA-Box?Binding Protein. Mol. Biol. Evol. 24: 1458-1463.
Amo, T., Brand, MD. (2007) Were inefficient mitochondrial haplogroups selected during radiations of modern humans? - A test using modular kinetic analysis of coupling in mitochondria from cybrid cell lines. Biochem. J. 404: 345-351.
2005~2006年度(平成17~18年)                            上へ
Ohta, S.(2006) Contribution of somatic mutations in the mitochondrial genome to the development of cancer and toloerance against anticancer drugs. Oncogene 25:4768-4776.
Ohta, S., Ohsawa, I.(2006) Dysfunction of mitochondria and oxidative stress in the pathogenesis of Alzheimer’s disease: On defects in the cytochrome c oxidase complex and aldehyde detoxification. J. Alzheimer’s Dis. 9: 155-166.
Suzuki, Y., Ando, F., Ohsawa, I., Shimokata, H., Ohta, S. (2006) Association of alcohol dehydrogenase 2*1 allele with liver damage and insulin concentration in the Japanese. J. Hum. Genet. 51:31-37.
Nakashima-Kamimura, N., Asoh, S., Ishibashi, Y., Mukai, Y., Shidara, Y., Oda, H., Munakata, K., Goto. Y., Ohta S.(2005) MIDAS/GPP34, a nuclear gene product, regulates total mitochondrial mass in response to mitochondrial dysfunction. J. Cell Sci. 118:5357-5367.
Yasukawa, T., Kirino, Y., Ishii, N., Lehtinen, SK., Jacobs, H.T., Makifuchi, T., Fukuhara, N., Shigeo Ohta., Suzuki, T., and Watanabe, K.(2005) Wobble modification deficiency in mutant tRNAs in patients with mitochondrial diseases. FEBS Lett. 579:2948-2952.
Uematsu, M., Ohsawa, I., Aokage, T., Nishimaki, K., Matsumoto, K., Takahashi, H. , Asoh, S., Teramoto, A. , Ohta, S. (2005) Prognostic significance of the immunohistchemical index of surviving in glioma. J. Neuro-Oncol. 72:231-238.
Asoh, S., Mori, T., Nagai, S., Yamagata, K., Nishimaki, K., Miyato, Y., Shidara, Y., Ohta, S.(2005) Zonal necrosis prevented by transduction of the artificial anti-death FNK protein. Cell Death Differ. ;12:384-394.
Shidara, Y., Yamagata, K., Kanamori, T., Nakano, K., Kwong JQ., Manfredi, G., Oda, H. , Ohta, S.(2005) Positive Contribution of Pathogenic Mutations in the Mitochondrial Genome to the Promotion of Cancer by Prevention from Apoptosis. Cancer Res. 65:1655-1663.
Sudo, K., Asoh, S., Ohsawa, I., Ozaki, D., Yamagata, K., Ito, H., Ohta S.(2005) The anti-cell death FNK protein protects cells from death induced by freezing and thawing. Biochem. Biophys. Res .Commun. 330:850-856.
Suzuki, Y., Atsumi, Y., Matsuoka, K., Nishimaki, K., Ohta, S., Taniyama, M. , Muramatsu, T.(2005) Mitochondrial tRNA(Leu(UUR)) mutation at position 3243 detected in patients with type 1 diabetes. Diabetes Res. Clin Pract. 67:92-94.
2001~2004年度(平成13~16年)                            上へ
Kirino, Y., Yasukawa, T., Ohta, S., Akira, S., Ishihara, K., Watanabe, K., Suzuki, T. (2004) Codon-specific translational defect caused by a wobble modification deficiency in mutant tRNA from a human mitochondrial disease. Proc. Natl. Acad. Sci. U S A. 101:15070-15075.
Suzuki, Y., Taniyama, M., Muramatsu, T., Higuchi, S., Ohta, S, Atsumi, Y., Matsuoka, K. (2004) ALDH2/ADH2 polymorphism associated with vasculopathy and neuropathy in type 2 Diabetes. Alcohol Clin. Exp. Res. 28 :111S-116S.
Suzuki, Y., Fujisawa, M., Ando, F., Niino, N., Ohsawa, I., Shimokata, H., Ohta, S. (2004) Alcohol dehydrogenase 2 variant is associated with cerebral infarction and lacunae. Neurology. 63:1711-1713.
Nomiyama, T., Tanaka, Y., Piao, L., Hattori, M., Uchino, H., Watada, H., Kawamori, R., Ohta, S.(2004) Accumulation of Somatic Mutation in Mitochondrial DNA and Atherosclerosis in Diabetic Patients. Ann. N.Y. Acad. Sci. 1011:193-204.
Ohsawa, I., Nishimura, T., Kondo, Y., Kimura, G., Satoh, M., Matsuzawa, I., Hamasaki, T., Ohta, S.(2004) Detection of urine survivin in 40 patients with bladder cancer. J. Nippon Med. Sch. 71:379-383.
Tanaka, M., Cabrera, VM., Gonzalez, AM., Larruga, JM., Takeyasu, T., Fuku, N., Guo, LJ., Hirose, R., Fujita, Y., Kurata, M., Shinoda, K., Umetsu, K., Yamada, Y., Oshida, Y., Sato, Y., Hattori, N., Mizuno, Y., Arai, Y., Hirose, N., Ohta, S., Ogawa, O., Tanaka, Y., Kawamori, R., Shamoto-Nagai, M., Maruyama, W., Shimokata, H., Suzuki, R., Shimodaira, H.(2004) Mitochondrial Genome Variation in Eastern Asia and the Peopling of Japan. Genome Res. 14:1832-1850.
Suzuki, Y., Nishimaki, K., Taniyama, M., Muramatsu, T., Atsumi, Y., Matsuoka, K., Ohta, S.(2004) Lipoma and opthalmoplegia in mitochondrial diabetes associated with small heteroplasmy level of 3243 tRNA(Leu(UUR)) mutation. Diabetes Res. Clin. Pract. 63:225-229.
Ohta, S., Ohsawa, I., Kamino,K., Ando, F., Shimokata, H. (2004) Mitochondrial ALDH2 Deficiency as an Oxidative Stress. Ann. N.Y. Acad. Sci. 1011: 36-44.
Suzuki, Y., Atsumi, Y., Matsuoka, K., Nishimaki, K., Ohta, S., Taniyama, M., Muramatsu, T.(2004) Acute metabolic cataract as a first manifestation of diabetes mellitus in a 12-year-old girl. Diabetologia. 47:592-593.
Mikami, T., Sumida, S., Ishibashi, Y., Ohta, S.(2004) Endurance exercise training inhibits activity of plasma GOT and liver caspase-3 of rats exposed to stress by induction of heat shock protein 70. J. Appl Physiol. 96:1776-1781.
Miyato, Y., Ando, K.(2004) Apoptosis of human melanoma cells by a combination of lonidamine and radiation. J. Radiat. Res. (Tokyo). 45:189-194.
Miyasaka, K., Yoshida, Y., Matsushita, S., Higuchi, S., Maruyama, K., Niino, N., Ando, F., Shimokata, H., Ohta, S., Funakoshi, A.(2004) Association of cholecystokinin-A receptor gene polymorphism with alcohol dependence in a Japanese population. Alcohol Alcohol. 39: 25-28.
Ozaki, D., Sudo, K., Asoh, S., Yamagata, K., Ito, H., Ohta, S. (2004) Transduction of anti-apoptotic proteins into chondrocytes in cartilage slice culture. Biochem. Biophys. Res .Commun 313: 522-527.
Aokage, T., Ohsawa, I., Ohta, S.(2004) Green fluorescent protein causes mitochondria to aggregate in the presence of the Bcl-2 family proteins. Biochem. Biophys. Res. Commun. 314: 711-716.
Ohsawa, I., Kamino, K., Nagasaka, K., Ando, F., Niino, N., Shimokata, H., Ohta, S. (2003) Genetic deficiency of a mitochondrial aldehyde dehydrogenase increases serum lipid peroxides in community-dwelling females. J. Hum. Genet. 48: 404-409.
Ohta, S. (2003) A Multi-Functional Organelle Mitochondrion is Involved in Cell Death, Proliferation and Disease. Curr. Med. Chem. 10: 2485-2494.
Suzuki, Y., Taniyama, M., Muramatsu, T. , Ohta, S., Murata, C. , Atsumi, Y. , Matsuoka, K. (2003) Mitochondrial tRNA(Leu(UUR)) mutation at position 3243 and symptomatic polyneuropathy in type 2 diabetes. Diabetes Care. 26:1315-1316.
Suzuki, Y., Kuriyama, S., Atsumi, Y. , Murata, C. , Matsuoka, K. , Taniyama, M. , Muramatsu, T., Ohta, S.(2003)Maternal inheritance of diabetes is associated with inactive ALDH2 genotype in diabetics with renal failure in Japanese. Diabetes Res. Clin. Pract. 60:143-145.
Nakano, K., Ohsawa, I., Yamagata, K., Nakayama,T., Sasaki, K., Tarashima, M., Saito, K., Osawa, M., Ohta, S. (2003) Continuous culture of novel mitochondrial cells lacking nuclei. Mitochondrion 3 :21-27.
Usui, K., Saijo, Y., Narumi, K., Koyama, S., Maemondo, M., Kikuchi, T., Tazawa, R., Hagiwara, K., Ishibashi, Y., Ohta, S., Nukiwa, T. (2003) N-terminal deletion augments the cell-death-inducing activity of BAX in adenoviral gene delivery to nonsmall cell lung cancers. Oncogene ;22:2655-2663.
Tahara, K., Tsuchimoto, D., Tominaga, Y., Asoh, S., Ohta, S., Kitagawa, M., Horie, H., Kadoya, T., Nakabeppu, Y. (2003) DeltaFosB, but not FosB, induces delayed apoptosis independent of cell proliferation in the Rat1a embryo cell line. Cell Death Differ. 10: 496-507.
Abe, H., Nishimura, T., Asoh, S., Ohta, S. (2003) Expression of Bcl-2 on leukocytes in prostatic fluid from patients with acute and chronic prostatitis. J. Infect. Chemother. 9: 156-159.
Okura, T., Koda, M., Ando, F., Niino, N., Ohta, S., Simokata, H. (2003) Assocation of polymorphisms in the estrogen receptor a gene with bdy fat distribution. Int. J. Obes. Relat. Metab. Disord. 27: 1020-1027.
Kanamori, T., Nishimaki, K., Asoh, S., Ishibashi,Y., Takata,I., Kuwabara, T.,Taira, K.,Yamaguchi, H.,Sugihara, S., Yamazaki, T.,Ihara, Y.,Nakano, K.,Matuda, S. and Ohta,S. (2003) Truncated product of the bifunctional DLST gene involved in biogenesis of the respiratory chain. The EMBO J. 22(12) :2913-2923.
Ohsawa, I., Nishimaki, K., Yasuda, C., Kamino, K., Ohta, S.(2003) Deficiency in a mitochondrial aldehyde dehydrogenase increases vulnerability to oxidative stress in PC12 cells. J. Neurochem. 84(5):1110-1117.
Suzuki, Y., Taniyama, M., Muramatsu, T., Ohta, S., Atsumi, Y., Matsuoka, K. (2003) Diabetic Vasculopathy and Alcohol Tolerance Trait in Type 2 Diabetes. Diabetes Care 26: 246-247.
Suzuki, Y., Taniyama, M. Muramatsu, T., Ohta, S., Atsumi, Y., Matsuoka, K. (2003) Influence of Alcohol Intake and Aldehyde Dehydrogenase 2 Phenotype on Peripheral Neuropathy of Diabetes. Diabetes Care 26: 249.
Harada, H., Nagai, H., Ezura, Y., Yokota, T., Ohsawa, I., Yamaguchi, K., Ohue, C., Tsuneizumi, M., Mikami, I., Terada, Y., Yabe, A., Emi, M. (2002)Down-regulation of a novel gene, DRLM, in human liver malignancy from 4q22 that encodes a NAP-like protein. Gene 296: 171-177.
Yasukawa, T., Suzuki, T., Ohta, S., Watanabe, K.(2002) Wobble modification defect suppresses translational activity of tRNAs with MERRF and MELAS mutations. Mitochondrion 2:129-141.
Nakano, K., Tanabe, M., Nakagawa, S., Ohta, S., Suzuki,S., Shimura, M., Matuda S.(2002) Isolation and sequence analysis of the rat dihydrolipoamide succinyltransferase gene. DNA Seq. 13(6) 363-367.
Yamamoto, H., Esaki,M.,, Kanamori,T., Tamura,Y., Nishikawa,S. (2002)Tim50 Is a subunit of the TIM23 complex that links protein translocation across the outer and inner mitochondrial membranes. Cell 111(4), 519-528.
Asoh, S., Ohsawa, I., Mori, T., Katsura, K., Hiraide, T., Katayama, Y., Kimura, M., Ozaki, D., Yamagata, K., Ohta, S. (2002) Protection against ischemic brain injury by protein therapeutics. Proc. Nat. Acad. Sci. USA. ; 99: 17107-17112.
Yamada, Y. ,Ando,F., Niino, N. , Ohta,S., Shimokata,H. (2002) Association of polymorphisms of the estrogen receptorαgene with bone mineral density of the femoral neck in elderly Japanese women. J. Mol. med. 80:452-460.
Nomiyama,T., Tanaka,Y., Hattori,N., Nishimaki,K., Nagasaka,K.,Kawamori, R. and Ohta,S. (2002)Accumulates a Somatic Mutation in Mitochondrial DNA extracted from peripheral blood cells in diabetic patients. Diabetologia. 45:1577-1583.
Hatanaka,Y., Nakae, D., Mutai, M., Hashizume, K., Kamihara, Y., Kinoshita N., Tani, Y., Danno, G., Ohta, S., Konishi, Y and Ashida, H(2001)Decreased Expression of Bcl-x Protein during Hepatocarcinogenesis Induced Exogenously and Endogenously in Rats.Jpn. J. Cancer Res.92 :1270-1277.
Ozaki, D., Shirai, Y. , Takeuchi, T., Ide, K., Nakase, T.(2001) Bilateral First Rib Fractures in Weight-lifting. Jpn. J. Orthopaedic Sports Med. 21: 11-16.
Yasukawa,T., Suzuki, T., Ishii, N., Ohta, S. and Watanabe, K. (2001). Wobble modifidation defect in tRNA disturbs codon-anticodon interaction in a mitochondrial disease. The EMBO J. 20: 4794-4802.
2000年度(平成12年)以前                               上へ
Asoh, S., Ohtsu, T., and Ohta, S. (2000). The Super Anti-apoptotic Factor Bcl-xFNK Constructed by Disturbing Intramolecular Polar Interactions in Rat Bcl-xL. J. Biol. Chem. 275, 37240-37245.
Hatanaka ,Y., Kamino, K., Fukuo, K., Mistuda, N., Nishiwaki-Ueda, Y., Sato, N., Satoh, T., Yamamoto, H., Yoneda, H., Imagawa, M., Miki, T., Ohta, S., and Ogihara, T.(2000). Low density lipoprotein receptor-related protein gene polymorphisms and risk for late-onset Alzheimer's disease in a Japanese population. Clinical Genet. 58(4),319-323.
Yasukawa ,T., Hino, T., Suzuki, T., Watanabe, K., Ueda, T. and Ohta, S. (2000). A pathogenic point mutation reduces stability of mitochondrial mutant tRNA(Ile). Nucleic Acids Res. tRNAlle. Nucl. Acids. Res. 28(19), 3779-3784.
Kamino, K., Nagasaka, K., Imagawa, M., Yamamoto, H., Yoneda , H., Ueki, A., Kitamura, S., Namekata, K., Miki, T., and Ohta, S. (2000). Deficiency in Mitochondrial Aldehyde Dehydrogenase Increases the Risk for Late-Onset Alzheimer's Disease in the Japanese Population. Biochem. Biophy. Res. Commun. 273, 192-196.
Nanbu-Wakao, R., Asoh, S., Nishimaki, K., Tanaka, R. and Ohta, S. (2000). Bacterial Cell death induced by human pro-apoptotic Bax is blocked by an RNaseE mutant that functions in an anti-oxidant pathway. genes to cells. 5, 155-167.
Yamada ,M., Mizuguchi, M., Nishimaki, K., Takasima, S., Ikeda, K., Ohta, S. and Takahashi, H. (2000). Localization of Bcl-xβ in the developing and adult rat central nervous system. J. Neurosci. Res. 60, 468-477.
Shimokata, H., Yamada, Y., Nakagawa, M, Okubo, R-i., Saido, T., Funakoshi, A., Miyasaka, K, Ohta, S., Tsujimoto, G., Tanaka, M., Ando, F. and Niino, N. (2000). Distribution of Geriatric Disease-Related genotypes in the National Institute for Longevity Sciences, Longitudinal Study of Aging(NILS-LSA). J.Epidemiol. 10, S46-S55.
Yasukawa, T., Suzuki, T., Suzuki, Ta., Ueda, T., Ohta, S. and Watanabe, K. (2000). Modification Defect at Anticodon Wobble Nucleotide of Mitochondrial tRNAs Leu(UUR) with Pathogenic mutations of Mitochondrial Myopathy, Encephalopathy,Lactic Acidosis, and Stroke-like Episodes. J.Biol.Chem. 275, 4251-4257.
Tanabe, T., Takata, I., Kuwabara, T., Warashina, M, Kawasaki, H., Tani, K., Ohta S., Asano, S., and Taira, K. (2000). Maxizymes,Novel Allosterically Controllable Ribozymes, Can Be Designed to Cleave Various Substrates.Biomacromlecules. 1, 108-117.
Yasukawa, T., Suzuki, T., Ishii, N., Ueda, T., Ohta, S. and Watanabe, K. (2000). Defect in Modification at the Anticodon Wobble Nucleotide of Mitochondrial tRNALys with the MERRF Encephalomyopathy Pathogenic Mutation. FEBS Lett. 467,175-178.
Asoh, S., Mori, T., and Ohta, S. (1999). Practicable recovery of plasmids carring cDNA encoding anti-apoptotic factors that had been introduced by particle bombardment into 5- week old rat hippocampal slices. Neurosci Lett. 272, 62-66.
Kamino, K., Wijsman, E., Anderson, L., Nemens, E., Yamagata, H., Ohta, S., Bird ,T.D., and Schellenberg, G.D. (1999). A family with late-onset Alzheimer's disease carrying Val91Met mutation of apolipoprotein A-II gene suggests altered plasma lipid metabolism in Alzheimer's disease. In: Alzheimer's disease & related disorders,( edited by K. Iqbal, D.F.Swaab, B.Winblad and H.M.Wisniewski.) John Wiley & Sons Ltd. 501-506.
Ito, S., Ohta, S., Nishimaki, K., Kagawa, Y., Miyazaki, R., Kuno, S-Y., Komatsuzaki ,Y., Mizusawa, H. and Hayashi, J-I. (1999). Functional integrity of mitochondrial genomes in human platelets and autopsied brain tissues from elderly patients with Alzheimer's disease. Proc. Natl. Acad. Sci. USA. 96, 2099-2103.
Taniguchi, F., Suzuki, Y., Shirato, S., and Ohta, S. (1999). Clinical phenotype of a Japanese primary open angle glaucoma family with a mutation in trabecular meshwork inducible glucocorticoid response gene. Jpn. J. Ophthalmol. 43, 80-84.
Yasukawa, T., Suzuki, T., Ueda, T., Hayashi, J-I., Ohta, S. and Watanabe, K. (1998). Stability of mitochondrial tRNA molecules with pathogenic point mutations. Nucleic Acids Symposium Series. 39, 257-258.
Asoh, S., Nishimaki, K., Nanbu-Wakao, R., and Ohta, S. (1998). A trace amount of the human proapoptotic factor Bax induces bacterial death accompanied by damage of DNA. J .Biol. Chem. 273, 11384-11391.
Ishibashi, Y., Nishimaki , K., Asoh, S., Nanbu-Wakao, R., Yamada ,T., and Ohta, S. (1998). Pore formation Domain of human pro-apoptotic Bax induces mammalian apoptosis as well as bacterial death without antogonizing anti-apoptotic facrors. Biochem. Biophys. Res. Commun. 245, 609-616.
Okazaki , M., Ishibashi ,Y., Asoh, S., and Ohta, S. (1998) Overexpressed mitochondrial Hinge protein, a cytochrome c binding protein accelerates apoptosis by enhancing the release of cytochrome c from mitochondria. Biochem. Biophys. Res. Commun. 243, 131-136.