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一般の皆さまへ
「 主 要 論 文 」
 2015~2009年度
 Iuchi, K., Imoto A., Kamimura N., Ichimiya H., Yokota T., Ohta S.(2016) Molecular hydrogen regulates gene expression by modifying the free radical chain reaction-dependent generation of oxidized phospholipid mediators. Sci Rep. 2;6:18971.
 Hayashida K, Sano M, Kamimura N, Yokota T, Suzuki M, Ohta S, Fukuda K, Hori S.(2014) Hydrogen inhalation during normoxic resuscitation improves neurological outcome in a rat model of cardiac arrest independently of targeted temperature management. Circulation. ;130(24):2173-80.
 Wolf AM, Nishimaki K, Kamimura N, Ohta S(2014) Real-time monitoring of oxidative stress in live mouse skin. J Invest Dermatol. 134(6):1701-9.
 Yoritaka A, Takanashi M, Hirayama M, Nakahara T, Ohta S, Hattori N.(2013) Pilot study of H₂ therapy in Parkinson's disease: a randomized double-blind placebo-controlled trial. Mov Disord.28(6):836-9.
 Hayashida K, Sano M, Kamimura N, Yokota T, Suzuki M, Maekawa Y, Kawamura A, Abe T, Ohta S, Fukuda K, Hori S.(2012) H(2) gas improves functional outcome after cardiac arrest to an extent comparable to therapeutic hypothermia in a rat model. J Am Heart Assoc. 1(5):e003459.
 Hoshi H, Hao W, Fujita Y, Funayama A, Miyauchi Y, Hashimoto K, Miyamoto K, Iwasaki R, Sato Y, Kobayashi T, Miyamoto H, Yoshida S, Mori T, Kanagawa H, Katsuyama E, Fujie A, Kitagawa K, Nakayama KI, Kawamoto T, Sano M, Fukuda K, Ohsawa I, Ohta S, Morioka H, Matsumoto M, Chiba K, Toyama Y, Miyamoto T.(2012) Aldehyde-stress resulting from Aldh2 mutation promotes osteoporosis due to impaired osteoblastogenesis. J Bone Miner Res. 27(9):2015-23.
 Rikimaru M, Ohsawa Y, Wolf AM, Nishimaki K, Ichimiya H, Kamimura N, Nishimatsu S, Ohta S, Sunada Y.(2012)Taurine ameliorates impaired the mitochondrial function and prevents stroke-like episodes in patients with MELAS. Intern Med. 2012;51(24):3351-7.
 Kashio A, Sakamoto T, Kakigi A, Suzuki M, Suzukawa K, Kondo K, Sato Y, Asoh S, Ohta S, Yamasoba T.(2012)Topical application of the antiapoptotic TAT-FNK protein prevents aminoglycoside-induced ototoxicity. Gene Ther. 19(12):1141-9.
 Kamimura N, Nishimaki K, Ohsawa I, Ohta S.(2011) Molecular hydrogen improves obesity and diabetes by inducing hepatic FGF21 and stimulating energy metabolism in db/db mice. Obesity (Silver Spring). 19(7):1396-403.
 Oharazawa H, Igarashi T, Yokota T, Fujii H, Suzuki H, Machide M, Takahashi H, Ohta S, Ohsawa I.(2010) Protection of the retina by rapid diffusion of hydrogen: administration of hydrogen-loaded eye drops in retinal ischemia-reperfusion injury. Invest Ophthalmol Vis Sci. 51(1):487-92.
 Wolf AM, Asoh S, Hiranuma H, Ohsawa I, Iio K, Satou A, Ishikura M, Ohta S.(2010) Astaxanthin protects mitochondrial redox state and functional integrity against oxidative stress. J Nutr Biochem. 21(5):381-9.
 Endo J, Sano M, Katayama T, Hishiki T, Shinmura K, Morizane S, Matsuhashi T, Katsumata Y, Zhang Y, Ito H, Nagahata Y, Marchitti S, Nishimaki K, Wolf AM, Nakanishi H, Hattori F, Vasiliou V, Adachi T, Ohsawa I, Taguchi R, Hirabayashi Y, Ohta S, Suematsu M, Ogawa S, Fukuda K.(2009) Metabolic remodeling induced by mitochondrial aldehyde stress stimulates tolerance to oxidative stress in the heart. Circ Res. 105(11):1118-27.
 Suzuki Y, Sano M, Hayashida K, Ohsawa I, Ohta S, Fukuda K.(2009) Are the effects of alpha-glucosidase inhibitors on cardiovascular events related to elevated levels of hydrogen gas in the gastrointestinal tract? FEBS Lett. 583(13):2157-9.


日本医科大学
大学院
医学研究科
加齢科学系専攻
細胞生物学分野

    (先端医学研究所     細胞生物学部門)

Fax: 044-733-9268


本ページに記載の記事・写真・カットの転載を禁じます。すべての著作権は生化学部門に帰属します。

(C)Copyright 2001, Dept. of Biochem. and Cell Biol.

最終更新日
16.01.16


 Nakashima-Kamimura N, Mori T, Ohsawa I, Asoh S, Ohta S.(2009) Molecular hydrogen alleviates nephrotoxicity induced by an anti-cancer drug cisplatin without compromising anti-tumor activity in mice. Cancer Chemother Pharmacol. 64(4):753-61.
  上へ
2007~2008年度 
  上へ
 Ohsawa, I., Nishimaki, K., Murakami, Y., Suziki Y., Ishikawa, M., Ohta S.(2008) Age-Dependent Neurodegeneration Accompanying Memory Loss in Transgenic Mice Defective in Mitochondrial Aldehyde Dehydrogenase 2 Activity. J. Neurosci.28: 6239-6249.
 Nagata, K., Nakashima-Kamimura, N., Mikami, T., Ohsawa, I., Ohta ,S.(2008) Consumption of Molecular Hydrogen Prevents the Stress-Induced Impairments in Hippocampus-Dependent Learning Tasks during Chronic Physical Restraint in Mice. Neuropsychopharmacology. in press.
 Katsura, K., Takahashi, K., Asoh, S., Watanabe, M., Sakurazawa, M., Ohsawa, I., Mori, T., Igarashi, H., Ohkubo, S., Katayama, Y., Ohta, S. (2008) Combination therapy with transductive anti-death FNK protein and FK506 ameliorates brain damage with focal transient ischemia in rat. J. Neurochem.106:258-270.
 Tara, S., Miyamoto, M., Asoh, S., Ishii, N., Yasutake, M., Takagi, G., Takano, T., Ohta, S. (2007)Transduction of the anti-apoptotic PTD-FNK protein improves the efficiency of transplantation of bone marrow mononuclear cells. J. Mol. Cell. Cardiol. 42: 489-497.
 Ohsawa, I., Ishikawa, M., Takahashi, K., Watanabe, M., Nishimaki, K., Yamagata, K., Katsura, K.-I., Katayama, Y., Asoh, S., Ohta, S. (2007) Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals. Nat. Med. 13:688-694.
 上へ
 2004~2006年度     
 上へ
 Asoh, S., Mori, T., Nagai, S., Yamagata, K., Nishimaki, K., Miyato, Y., Shidara, Y., Ohta, S. (2005) Zonal necrosis prevented by transduction of the artificial anti-death FNK protein. Cell Death Differ.12: 384-394.
 Shidara, Y., Yamagata, K., Kanamori, T., Nakano, K., Kwong JQ., Manfredi, G., Oda, H., Ohta, S. (2005) Positive Contribution of Pathogenic Mutations in the Mitochondrial Genome to the Promotion of Cancer by Prevention from Apoptosis. Cancer Res.65: 1655-1663.
 Kirino, Y., Yasukawa, T., Ohta, S., Akira, S., Ishihara, K., Watanabe, K., Suzuki, T. (2004) Codon-specific translational defect caused by a wobble modification deficiency in mutant tRNA from a human mitochondrial disease. Proc. Natl. Acad. Sci. U S A. 101:15070-15075.
 Suzuki, Y., Fujisawa, M., Ando, F., Niino, N., Ohsawa, I., Shimokata, H., Ohta, S. (2004) Alcohol dehydrogenase 2 variant is associated with cerebral infarction and lacunae.Neurology.63: 1711-1713.
 2001~2003年度
Kanamori, T., Nishimaki, K., Asoh, S., Ishibashi,Y., Takata, I., Kuwabara, T., Taira, K., Yamaguchi, H., Sugihara, S., Yamazaki, T., Ihara, Y., Nakano, K., Matuda, S. and Ohta, S. (2003) Truncated product of the bifunctional DLST gene involved in biogenesis of the respiratory chain. EMBO J. 22 (12): 2913-2923.
Ohsawa, I., Nishimaki, K., Yasuda, C., Kamino, K., Ohta, S. (2003) Deficiency in a mitochondrial aldehyde dehydrogenase increases vulnerability to oxidative stress in PC12 cells. J. Neurochem. 84 (5):1110-1117.
Nomiyama, T., Tanaka, Y., Hattori, N., Nishimaki, K., Nagasaka, K., Kawamori, R., Ohta, S.(2002) : Accumulationa of somatic mutation in Mitochondrial DNA extracted from peripheral blood cells in diabetic patients. Diabetologia. ; 45: 1577-1583.
Asoh, S., Ohsawa, I., Mori, T., Katsura, K., Hiraide, T., Katayama, Y., Kimura, M., Ozaki, D., Yamagata, K. and Ohta, S. (2002) Protection against ischemic brain injury by protein therapeutics. Proc. Natl. Acad. Sci. USA. 99: 17107-17112.
Yasukawa,T., Suzuki, T., Ishii, N., Ohta, S. and Watanabe, K. (2001) Wobble modifidation defect in tRNA disturbs codon-anticodon interaction in a mitochondrial disease. EMBO J. 20, 4794-4802.
2000年度以前                         
Yasukawa, T., Suzuki, T., Suzuki, Ta., Ueda, T., Ohta, S. and Watanabe, K. (2000) Modification Defect at Anticodon Wobble Nucleotide of Mitochondrial tRNAs LEU(UUR) with Pathogenic mutations of Mitochondrial Myopathy, Encephalopathy,Lactic Acidosis, and Stroke-like Episodes. J.Biol.Chem. 275, 4251-4257.
Kamino, K., Nagasaka, K., Imagawa, M., Yamamoto, H., Yoneda , H., Ueki, A., Kitamura, S., Namekata, K., Miki, T., and Ohta, S. (2000) Deficiency in Mitochondrial Aldehyde Dehydrogenase Increases the Risk for Late-Onset Alzheimer's Disease in the Japanese Population. Biochem. Biophy. Res. Commun. 273, 192-196.
Asoh, S., Ohtsu, T., and Ohta, S. (2000) The Super Anti-apoptotic Factor Bcl-xFNK Constructed by Disturbing Intramolecular Polar Interactions in Rat Bcl-xL. J. Biol. Chem. 275, 37240-37245.
Ito, S., Ohta, S., Nishimaki, K., Kagawa, Y., Miyazaki, R., Kuno, S-Y., Komatsuzaki ,Y., Mizusawa, H. and Hayashi, J-I. (1999) Functional integrity of mitochondrial genomes in human platelets and autopsied brain tissues from elderly patients with Alzheimer's disease. Proc. Natl. Acad. Sci. USA. 96, 2099-2103.
Asoh, S., Nishimaki, K., Nanbu-Wakao, R., and Ohta, S. (1998) A trace amount of the human proapoptotic factor Bax induces bacterial death accompanied by damage of DNA. J .Biol. Chem. 273, 11384-11391.
Nakano, K., Ohta, S., Nishimaki, K., Miki, T., and Matuda, S. (1997) Alzheimer's disease and DLST genotype. Lancet . 350, 1367-1368.