The prevalence of atopic dermatitis has continued to increase in modern, highly industrialized countries. One concept to explain the increase is the hygiene hypothesis, which suggests that the increase in allergic disease is caused by a decreased exposure to childhood infections. After the hygiene hypothesis was described, epidemiological studies have been performed to evaluate the hypothesis from a standpoint of Th1/Th2 balance, and antiallergic therapies using microbes have been described. In this paper, novel strategies for the treatment of atopic dermatitis are introduced, including systemic immunotherapy using dinitrochlorobenzene and early intervention therapy and immunotherapy based on the hygiene hypothesis.
ϊγεγο 2005; 1(4), 207-209