Intraocular Inflammation and Antigen Presentation
Department of Vision and Ophthalmology, Graduate School of Medicine, Nippon Medical School
Department of Ophthalmology, Nippon Medical School Chiba Hokusoh Hospital
Intraocular space is thought to be an immune privileged site. One of the most well known facts is that the corneal plantation is successful even if the donor's MHC molecules doesn't match with the recipient's. However, still this doesn't mean that the immune reaction is completely inhibited in the intraocular tissue, since the intraocular herpes infection develops fulminate immune inflammation known as acute retinal necrosis.
For explaining these complicated intraocular immune responses, in which some immune reactions are inhibited while others develop immuneinflammation, it is required to study the antigen presenting process in the intraocular tissue. And since there isn't much reports about whether the antigen presentation process in the intraocular tissue takes place or not in this paper we show preliminary results indicating the existence of potential cells able to present antigens. We also review recent literature reporting the immune reactions in intraocular tissue and central nervous systems.
ϊγεγο 2008; 4(1), 8-14
antigen presentation, intraocular tissue, antigen uptake, antigen presenting cells
Kunihiko Yamaki, Department of Ophthalmology, Nippon Medical School Chiba Hokusoh Hospital, 1715 Kamagari Inba-mura, Inba-gun, Chiba, 270-1694, Japan