Chemical Reaction of Drug Metabolism: Reactivity of cytochrome P450
Department of Chemistry, Nippon Medical School
Drug metabolism involves chemical reactions modifying pharmaceutical substances. Lipophilic chemical compounds are converted to hydrophilic compounds by enzymes related to drug metabolism. Some drugs are activated after drug metabolism; on the other hand, some xenobiotic compounds become toxic through these enzymes. Cytochrome P450 is an enzyme that plays a major role in drug metabolism. Metabolites produced by cytochrome P450 from one drug are predictable from the viewpoint of chemical reactivity. Novel metabolites from nonylphenol and bisphenol A are discovered considering the ipso-position metabolic reaction of cytochrome P450.
日医大医会誌 2013; 9(1), 25-30
cytochrome P450, drug metabolism, endocrine disruptor, ipso-addition, ipso-substitution
Shigeo Nakamura, Department of Chemistry, Nippon Medical School, 2-297-2 Kosugi-cho, Nakahara-ku, Kawasaki, Kanagawa 211-0063, Japan