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Last Update, 19 December 2011
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Matsumoto J, Urakawa S, Hori E, de Araujo M, Sakuma Y, Ono T, Nishijo H: Neuronal responses in the nucleus accumbens shell
during sexual behavior in male rats. Journal of Neuroscience 32(5): 1672-1686, February 1, 2012. doi: 10.1523/JNEUROSCI.5140-11.2012
Koyama M, Yin C, Ishii H, Sakuma Y, Kato M: Somatostatin inhibition of GnRH neuronal activity and the morphological relationship
between GnRH and somatostatin neurons in rats. Endocrinology 153(2): 806-814, February 2012. Published online on 6 December 2011 as doi:10.1210/en.2011-1374 Editorial Comment on this article by Suter KJ: Endocrinology 153(2): 552-553, February 2012 doi: 10.1210/en.2011-2076
Dhungel S, Masaoka M, Rai D, Kondo Y, Sakuma Y: Both olfactory epithelial and vomeronasal inputs are essential for activation of
the medial amygdala and preoptic neurons of male rats. Neuroscience 199: 225-234, 29 December 2011. Accepted for publication on 27 September 2011. doi:10.1016/j.neuroscience.2011.09.051
Ishii H, Sakuma Y: Complex organization of the 5'-untranslated region of the mouse estrogen receptor alpha gene: Identification
of numerous mRNA transcripts with distinct 5'-ends. Journal of Steroid Biochemistry and Molecular Biology 125(3/5): 211-218, July 2011. Accepted for publication on 4 March 2011. doi:10.1016/j.jsbmb.2011.03.004
Ishii H, Shoda Y, Yomogida K, Hamada T, Sakuma Y: Identification of C-terminally and N-terminally truncated estrogen
receptor a variants in the mouse. Journal of Steroid Biochemistry and Molecular Biology 124(1/2): 38-46, March 2011. Accepted for publication on 12 January 2011. doi:10.1016/j.jsbmb.2011.01.003
Kobayashi M, Ishii H, Sakuma Y: Identification of novel splicing events and post-transcriptional regulation of human estrogen
receptor a F isoforms. Molecular and Cellular Endocrinology 333(1): 55-61, February 2011. Accepted for publication on 3 December 2010. doi:10.1016/j.mce.2010.12.003
Dhungel S, Urakawa S, Kondo Y, Sakuma Y: Olfactory preference in the male rat depends on multiple chemosensory inputs
converging on the preoptic area. Hormones and Behavior 59(1): 193-199, January 2011. Published online on 20 November 2010 as doi:10.1016/j.yhbeh.2010.11.011
Orikasa C, Kondo Y, Usui S, Sakuma Y: Similar numbers of neurons are generated in the male and female rat preoptic area
in utero. Neuroscience Research 68(1): 9-14, 10 September 2010. Published online on 9 June 2010 as doi:10.1016/j.neures.2010.05.008
Orikasa C, Sakuma Y: Estrogen configures the sexual dimorphism in the preoptic area of C57/BL6J and ddN strains of mice.
Journal of Comparative Neurology 518(17): 3618-3629, 1 September 2010. Wiley Accepted Article Online on 20 May 2010 as doi:10.1002/cne.22419
Hamada T, Sakuma Y: Estrogen receptor a gene promoter 0/B usage in the rat sexually dimorphic nucleus of the preoptic area.
Endocrinology 151(4): 1923-1928, April 2010. Published online on 25 February 2010 as doi:10.1210/en.2009-1022
Tanaka N, Ishii H, Yin C, Koyama M, Sakuma Y, Kato M: Voltage-gated Ca2+ channel mRNAs and T-type Ca2+ currents in
rat gonadotropin-releasing hormone neurons. Journal of Physiological Sciences 60(3): 195-204, May 2010. Published online on 26 January 2010 as doi:10.1007/s12576-010-0085-z Awarded 2010 Irisawa Prize, The Physiological Society of Japan
Ishii H, Kobayashi M, Sakuma Y: Alternative promoter usage and alternative splicing of the rat estrogen receptor a gene
generate numerous mRNA variants with distinct 5'-ends. Journal of Steroid Biochemistry and Molecular Biology 118(1/2): 59-69, January 2010. Published online on October 13, 2009 as doi:10.1016/j.jsbmb.2009.10.001
Watanabe M, Sakuma Y, Kato M: GABAA receptors mediate excitation in adult rat GnRH neurons. Biology of Reproduction
81(2): 327-332, August 1, 2009. Published online on April 8, 2009 as doi:10.1095/biolreprod.108.074583
Ishii H, Sato S, Yin C, Sakuma Y, Kato M: Cetrorelix, a gonadotropin-releasing hormone antagonist, induces the expression of melatonin
receptor 1a in the gonadotropin-releasing hormone neuronal cell line GT1-7. Neuroendocrinology 90(3):251-259, September 2009. Published online on July 30, 2009 as doi:10.1159/000231993 Cover of this issue features a figure in this article.
Sakuma Y: Gonadal steroid action and brain sex differentiation in the rat. Journal of Neuroendocrinology 21(4):410-414, April 2009.
Kato M, Tanaka N, Ishii H, Yin C, Sakuma Y: Ca2+ channels and Ca2+-activated K+ channels in adult rat gonadotropin-releasing
hormone neurones. Journal of Neuroendocrinology 21(4):312-315, April 2009. doi:10.1111/j.1365-2826.2009.01849.x
Ishii H, Tanaka N, Kobayashi M, Kato M, Sakuma Y: Gene structures, biochemical characterization and distribution of rat melatonin
receptors. Journal of Physiological Sciences 59(1): 37-47, January 2009. E-pub on December 6, 2008 as doi:10.1007/s12576-008-0003-9 Awarded 2009 Irisawa Prize, The Physiological Society of Japan
Sato S, Yin C, Teramoto A, Sakuma Y, Kato M: Sexually dimorphic modulation of GABAA receptor currents by melatonin
in rat gonadotropin-releasing hormone neurons. Journal of Physiological Sciences 58(5): 317-322, November 2008. Epub 2008 Oct 7. doi:10.2170/physiolsci.RP006208 Awarded 2008 Irisawa Prize, The Physiological Society of Japan
Xu Q, Hamada T, Kiyama R, Sakuma Y, Wada-Kiyama Y: Site-specific regulation of gene expression by estrogen
in the hypothalamus of adult female rats. Neuroscience Letters 436(1): 35-39, 2 May 2008. Published online 29 February 2008 as doi:10.1016/j.neulet.2008.02.054
Sakuma Y: Neural substrates for sexual preference and motivation in the female and male rat.
Annals of New York Academy of Sciences 1129: 55-60, June 2008. Published online as doi:10.1196/annals.1417.009
Yin C, Ishii H, Tanaka N, Sakuma Y, Kato M: Activation of A-type g-amino butyric acid receptors (GABAARs) excites
gonadotropin-releasing hormone (GnRH) neurons isolated from adult rats. Journal of Neuroendocrinology 20(5): 566-575, May 2008. Published on line on March 17, 2008 as doi: 10.1111/j.1365-2826.2008.01697.x
Hiraizumi Y, Nishimura I, Ishii H, Tanaka N, Takeshita T, Sakuma Y, Kato M: Rat GnRH neurons exhibit large conductance voltage- and
Ca2+-activated K+ (BK) currents and express BK channel mRNAs. Journal of Physiological Sciences 58(1): 21-29, February 2008. Published on line ahead of print on January 8, 2008 as doi:10.2170/physiolsci.RP013207
Sakuma Y: Mechanisms for brain sex differentiation. Hirosaki Medical Journal 59 (Suppl): S253-S261, 2007
Nishimura I, Ui-Tei K, Saigo K, Ishii H, Sakuma Y, Kato M: 17b-Estradiol at physiological concentrations
augments BK currents via estrogen receptor b in the GnRH neuronal cell line GT1-7. Endocrinology 149(2): 774-782, February 2008. Published on line ahead of print on October 25, 2007 as doi:10.1210/en.2007-0759
Kitahashi T, Ogawa S, Soga T, Sakuma Y, Parhar IS: Sexual maturation modulates expression of
nuclear receptor types in laser-captured single cells of the cichlid (Oreochromis niloticus) pituitary. Endocrinology 148(12): 5822-5830, December 2007. Published on line ahead of print on September 6, 2007 as doi:10.1210/en.2007-0311
Orikasa C, Kondo Y, Sakuma Y: Transient transcription of the somatostatin gene at the time of estrogen-
dependent organization of the sexually dimorphic nucleus of the rat preoptic area. Endocrinology 148(3): 1144-1149, March 2007. Published on line on November 30, 2006 as doi:10.1210/en.2006-1214
Takenoya F, Guan JL, Kato M, Sakuma Y, Kintaka Y, Kitamura Y, Kitamura S, Okuda H,
Takeuchi M, Kageyama H, Shioda S: Neural interaction between galanin-like peptide (GALP)- and luteinizing hormone-releasing hormone (LHRH)-containing neurons. Peptides 27(11): 2885-2893, Nov 2006. Published online ahead of print on Jun 19, 2006 as doi:10.1016/j.peptides.2006.05.012
Kato M, Tanaka N, Usui S, Sakuma Y: SK channel blocker apamin inhibits slow after-
hyperpolarization currents in rat gonadotropin-releasing hormone neurones. Journal of Physiology 574(Pt 2): 431-442, Jul 15, 2006, Published on line ahead of print on Apr 20, 2006 as doi:10.1113/jphysiol.2006.110155
Kondo Y, Sakuma Y: The medial amygdala controls coital access of female rats: A possible
involvement of emotional responsiveness. Japanese Journal of Physiology 55(6): 345-353, Dec 2005. Published on line ahead of print on Jan 17, 2006 as doi:10.2170/jjphysiol.RP001105
Kitahashi T, Sato H, Sakuma Y, Parhar IS: Cloning and functional analysis of promoters of three
GnRH genes in a Cichlid. Biochemical and Biophysical Research Communications 336(2): 536-543, 21 October 2005. Published on line ahead of print on August 25, 2005 as doi:10.1016/j.bbrc.2005.08.122
Hamada T, Wada-Kiyama Y, Sakuma Y: Visualizing forebrain-specific usage of an estrogen receptor
alpha promoter for receptor down regulation in the rat. Molecular Brain Research 139(1): 42-51, September 13, 2005. Published on line ahead of print on June 13, 2005 as doi:10.1016/j.molbrainres.2005.05.019
Ogawa S, Akiyama G, Kato S, Soga T, Sakuma Y, Parhar IS: Immunoneutralization of
gonadotropin-releasing hormone type-III suppresses male reproductive behavior of cichlids. Neuroscience Letters 403(3): 201-215, 7 August 2006, doi:10.1016/j.neulet.2006.02.041
Uchida H, Ogawa S, Harada M, Matushita M, lwata M, Sakuma Y, Parhar IS: Surgical removal of
the olfactory epithelium modulates reproductive behaviors and gonadotropin-releasing hormone (GnRH) subtypes in tilapia oreochromis niloticus. Journal of Neurobiology 65(1): 1-11, July 7, 2005. Published on line as doi:10.1002/neu.20156
Soga T, Ogawa S, Millar RP, Sakuma Y, Parhar IS: Immunocytochemical localization of
gonadotropin-releasing hormone receptor subtypes in the developing brain of Cichlid fish. Journal of Comparative Neurology 487(1): 28-41, June 20, 2005. Published online before print on April 28, 2005 as doi:10.1002/cne.20519
Parhar IS, Soga T, Ogawa S, Ogawa S, Pfaff DW, Sakuma Y: Nonmammalian forms of
gonadotropin-releasing hormone molecules in the brain of promoter transgenic rats. Proceedings of the National Academy of Sciences of the United States of America 102(16): 5880-5885, April 19, 2005. Published online before print on April 11, 2005 as an Open Access Article with free access to full text, doi:10.1073/pnas.0501832102
Xiao K, Kondo Y, Sakuma Y: Differential regulation of female rat olfactory preference and
copulatory pacing by the lateral septum and medial preoptic area. Neuroendocrinology 81(1): 56-62, 2005. First published online on April 4, 2005 as doi:10.1159/000084893
Parhar IS, Ogawa S, Sakuma Y: Three GnRH receptor types in laser captured single cells of the
cichlid pituitary display cellular and functional heterogeneity. Proceedings of the National Academy of Sciences of the United States of America 102(6):2204-2209, February 8, 2005. Published online before print on January 27, 2005 as an Open Access Article with free access to full text, doi:10.1073/pnas.0409494102
Orikasa C, Sakuma Y: Sex and region-specific regulation of oestrogen receptor beta in the rat
hypothalamus. Journal of Neuroendocrinology 16(6): 964-969, 2004. First published online on December 23, 2004 as doi:10.1111/j.1365-2826.2004.01254.x
Xiao K, Kondo Y, Sakuma Y: Sex-specific effects of gonadal steroids on conspecific odor preference
in the rat. Hormones and Behavior 46(3): 356-361, September 2004. doi:10.1016/j.yhbeh.2004.05.008
Rho JY, Wada-Kiyama Y, Onishi Y, Kiyama R, Sakuma Y: Expressional regulation of neuronal and
cancer-related genes by estrogen in adult female rats. Endocrine Research 30(2): 257-267, September 2004. First published August 16, 2004 as doi:10.1081/ERC-120039579
Parhar IS, Ogawa S, Sakuma Y: Laser-captured single digoxigenin-labeled neurons of gonadotropin-
releasing hormone types reveal a novel G protein-coupled receptor (Gpr54) during maturation in cichlid fish. Endocrinology 145(8): 3613-3618, August 2004. Published online on May 20, 2004 as doi:10.1210/en.2004-0395
Terasaka S, Aita Y, Inoue A, Hayashi S, Nishigaki M, Aoyagi K, Sasaki H, Wada-Kiyama Y,
Sakuma Y, Akaba S, Tanaka J, Sone H, Yonemoto J, Tanji M, Kiyama R: Expression profiling of the estrogen responsive genes for evaluation of estrogen activity among natural estrogens and industrial chemicals using a customized DNA microarray. Environmental Health Perspectives Toxicogenomics 112(7): 773-781, May 2004. First published February 12, 2004 as doi:10.1289/txg.6753
Watanabe M, Sakuma Y, and Kato M: High expression of the R-type voltage-gated Ca2+ channel
and its involvement in Ca2+-dependent GnRH release in GT1-7 cells. Endocrinology 145(5): 2375-2383, May 2004. First published January 21, 2004 as doi:10.1210/en.2003-1257
Orikasa C, Sakuma Y: Possible involvement of preoptic estrogen receptor beta positive cells in
luteinizing hormone surge in the rat. Domestic Animal Endocrinology 25(1):83-92, July 2003. doi:10.1016/S0739-7240(03)00047-X
Kato M, Ui-Tei K, Watanabe M, Sakuma Y: Characterization of voltage-gated calcium currents in
gonadotropin-releasing hormone neurons tagged with green fluorescent protein in rats. Endocrinology 144(11): 5118-5125, 2003. Published online on August 13, 2003 as doi:10.1210/en.2003-0213
Parhar IS, Soga T, Ogawa S, Sakuma Y: FSH and LH-beta subunits in the preoptic nucleus:
Ontogenic expression in teleost. General and Comparative Endocrinology 132(3): 369-378, 2003. Cover of this issue features a figure in this article. doi:10.1016/S0016-6480(03)00121-7
Parhar IS, Ogawa S, Hamada T, Sakuma Y: Single-cell real-time quantitative PCR of immunofluo-
rescently identified neurons of GnRH subtypes in cichlid fish. Endocrinology 144(8): 3297-3300, 2003. Published online on June 5, 2003 as doi:10.1210/en.2003-0386
Parhar IS, Sato H, Sakuma Y: Ghrelin gene in cichlid fish is modulated by sex and development.
Biochemical and Biophysical Research Communications 305(1): 169-175, 2003. doi:10.1016/S0006-291X(03)00729-0
Ohnishi H, Kondo Y, Sakuma Y: Oestrogen-induced vigorous mounting in female rats carrying
hypothalamic knife cuts. Journal of Neuroendocrinology 15(6): 602-606, 2003. doi:10.1046/j.1365-2826.2003.01040.x
Kondo Y, Sudo T, Tomihara K, Sakuma Y: Activation of accessory olfactory bulb neurons during
copulatory behavior after deprivation of vomeronasal inputs in male rats. Brain Research 962(1/2): 232-236, 2003. doi:10.1016/S0006-8993(02)03970-7
Li XM, Onishi Y, Kuwabara K, Rho JY, Wada-Kiyama Y, Sakuma Y, Kiyama R: Ligand-
dependent transcriptional enhancement by DNA curvature between two half motifs of the estrogen response element in the human estrogen receptor alpha gene. Gene 294(1/2): 279-290, 2002. doi:10.1016/S0378-1119(02)00803-X
Kaneishi K, Sakuma Y, Kobayashi H, Kato M: 3',5'-Cyclic adenosine monophosphate augments
intracellular Ca2+ concentration and gonadotropin-releasing hormone (GnRH) release in immortalized GnRH neurons in an Na+-dependent manner. Endocrinology 143(11): 4210-4217, 2002.
Parhar IS, Soga T, Sakuma Y, Millar RP: Spatio-temporal expression of GnRH receptor subtypes in
gonadotropes, somatotropes and lactotropes in the cichlid fish. Journal of Neuroendocrinology 14(8): 657-665, 2002. doi:10.1046/j.1365-2826.2002.00817.x
Orikasa C, Kondo Y, Hayashi S, McEwen BS, Sakuma Y: Sexually dimorphic expression of
estrogen receptor b in the anteroventral periventricular nucleus of the rat preoptic area: Implication in luteinizing hormone surge.Proceedings of the National Academy of Sciences of the United States of America 99(5): 3306-3311, 2002; published online before print February 19 2002 as doi:10.1073/pnas.052707299
Ishihara T, Orikasa C, Araki T, Sakuma Y: Sex differences in the expression and regulation of nitric
oxide synthase gene in the rat preoptic area. Neuroscience Research 43(2): 147-154, 2002. doi:10.1016/S0168-0102(02)00025-1
Sakuma Y: Different subsets of preoptic neurons for proceptive and receptive components of female
rat sexual behavior. In: Neuroplasticity, Development, and Steroid Hormone Action, ed by RJ Handa et al., pp.243-256, CRC Press, Boca Raton, 2002.
Sudo T, Sakuma Y, Kato M: Bradykinin and angiotensin II-induced [Ca2+]i rise in cultured rat
pituitary folliculo-stellate cells. Journal of Neuroendocrinology 13(11): 942-950, 2001. doi:10.1046/j.1365-2826.2001.00699.x
Miura T, Kondo Y, Akimoto M, Sakuma Y: Electromyography of male rat perineal musculature
during copulatory behavior. Urologia Internationalis 67(3): 240-245, 2001. doi:10.1159/000050996
Parhar IS, Tosaki H, Sakuma Y, Kobayashi M: Sex differences in the brain of goldfish: Gonado-
tropin-releasing hormone and vasotocinergic neurons. Neuroscience 104(4): 1099-1110, 2001. doi:10.1016/S0306-4522(01)00153-1
Uchiyama M, Nakajima Y, Sakuma Y, Kato M: Purinergic regulation of intracellular Ca2+ concent-
ration of rat pituitary folliculo-stellate cells in primary culture. Journal of Neuroendocrinology 13(4): 378-385, 2001. doi:10.1046/j.1365-2826.2001.00639.x
Nakajima Y, Uchiyama M, Shirai Y, Sakuma Y, Kato M: Acetylcholine increases intracellular Ca2+
in the rat pituitary folliculostellate cells in primary culture. American Journal of Physiology: Endocrinology and Metabolism 280(4): E608-E615, 2001.
Kato A, Sakuma Y: Neuronal activity in female rat preoptic area associated with sexually motivated
behavior. Brain Research 862(1/2): 90-102, 2000. doi:10.1016/S0006-8993(00)02076-X
Orikasa C, McEwen BS, Hayashi H, Sakuma Y, Hayashi S: Estrogen receptor alpha, but not beta, is
expressed in hippocampal interneurons in prepuberal rats: An in situ hybridization study. Developmental Brain Research 120(2): 245-254, 2000. doi:10.1016/S0165-3806(00)00016-X
Du J, Sudo T, Sakuma Y, Kato M: Angiotensin II increases intracellular Ca2+ concentration in
folliculo-stellate cells of the rat anterior pituitary in primary culture. Brain Research 859(1): 167-168, 2000. doi:10.1016/S0006-8993(99)02467-1
Parhar IS, Soga T, Sakuma Y: Thyroid hormone and estrogen regulate brain region-specific
messenger ribonucleic acids encoding three gonadotropin-releasing hormone genes in sexually immature male fish Oreochromis Niloticus. Endocrinology 141(5): 1618-1626, 2000.
Kato M, Sakuma Y: The effect of GHRP-6 on the intracellular Na+ concentration of rat pituitary cells
in primary culture. Journal of Neuroendocrinology 11(10): 795-800, 1999. doi:10.1046/j.1365-2826.1999.00394.x
Chiba H, Nakamura M, Iwata M, Sakuma Y, Yamauchi K, Parhar IS: Development and
differentiation of gonadotropin hormone-releasing hormone neuronal systems and testes in the Japanese eel (Anguilla japonica). General and Comparative Endocrinology 114(3): 449-459, 1999. doi:10.1006/gcen.1999.7275
Kondo Y, Tomihara K, Sakuma Y: Sensory requirement for non-contact penile erection in the rat.
Behavioral Neuroscience 113(5):1062-1070, 1999. doi:10.1037//0735-7044.113.5.1062
Wada-Kiyama Y, Kuwabara K, Sakuma Y, Onishi Y, Trifonov EN, Kiyama R: Localization of
curved DNA and its association with nucleosome phasing in the promoter region of the human estrogen receptor a gene. FEBS Letters 444(1):117-124, 1999. doi:10.1016/S0014-5793(99)00041-1
Parhar IS, Soga T, Sakuma Y: Quantitative in situ hybridization of three gonadotropin-releasing
hormone-encoding mRNAs in castrated and progesterone-treated male tilapia. General and Comparative Endocrinology 112(3):406-414, 1998. doi:10.1006/gcen.1998.7143
Parhar IS, Soga T, Ishikawa Y, Nagahama Y, Sakuma Y: Neurons synthetizing gonadotropin-
releasing hormone mRNA subtypes have multiple developmental origins in the medaka. Journal of Comparative Neurology 401(2):217-226, 1998. doi:10.1002/(SICI)1096-9861(19981116)401:2<217::AID-CNE5>3.0.CO;2-V
Soga T, Sakuma Y, Parhar IS: Testosterone differentially regulates expression of GnRH messenger
RNAs in the terminal nerve, preoptic and midbrain of male tilapia. Molecular Brain Research 60(1):13-20, 1998. doi:10.1016/S0169-328X(98)00153-3
Tashiro S, Kondo Y, Sakuma Y: Temporal coincidence between the excitation of ventromedial
hypothalamic efferents and the induction of lordosis reflex in ovariectomized estrogen-primed rats.
Endocrine Journal 45(4):519-528, 1998.

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